4-Nitrophenyl Chloroformate
4-Nitrophenyl Chloroformate (CAS 7693-46-1), min. 98.5% GC, supplied wholesale by Zyntex. Activating reagent for carbamates and carbonates in drug synthesis, prodrugs, PEGylation and ADC linker chemistry. CoA and SDS.
Description
4-Nitrophenyl Chloroformate Product Overview
4-Nitrophenyl chloroformate (C7H4ClNO4) is a white to slightly yellow crystalline solid that melts at about 77–80°C. It also reacts readily with alcohols and amines and hydrolyzes in moist air.
Chemists use it to convert alcohols into activated 4-nitrophenyl carbonates, which then react cleanly with amines to form carbamates. This two-step activation is a standard method in drug synthesis, in the preparation of prodrugs, and in linker chemistry for PEGylation and antibody–drug conjugates. Similarly, released 4-nitrophenol has a yellow color, which helps chemists follow the reaction.
Furthermore, other chloroformates in our range include 2-Ethylhexyl chloroformate and n-Pentyl chloroformate; for isocyanate building blocks, see 4-Chlorophenyl isocyanate.
Key Applications of 4-Nitrophenyl Chloroformate
Typical uses include, for example:
💊 Drug Synthesis
Activation of alcohols for carbamate formation.
🔗 Bioconjugation
Linker chemistry for PEGylation as well as ADCs.
🧪 Prodrugs
Reagent for carbonate as well as carbamate prodrugs.
🔬 Peptide Chemistry
Activating agent in peptide modification.
4-Nitrophenyl Chloroformate Technical Specifications
| Parameter | Standard Value |
|---|---|
| Product Name | 4-Nitrophenyl Chloroformate |
| CAS Number | 7693-46-1 |
| Molecular Formula / Weight | C7H4ClNO4 / 201.56 g/mol |
| Purity (GC) | Minimum 98.5% |
| Appearance | White to slightly yellow crystals |
| Documents | CoA as well as SDS with every lot |
⚠️ Safety & Handling: Causes severe skin burns and eye damage and may cause allergic skin reactions; reacts with water, releasing hydrogen chloride. Handle in a fume hood under dry conditions, and also wear chemical-resistant gloves and face protection. Store refrigerated in tightly closed containers, away from moisture. Always consult the Safety Data Sheet (SDS), because it contains the full classification and handling instructions.
Frequently Asked Questions
Why is 4-nitrophenyl chloroformate popular for carbamate synthesis?
Because the activated carbonate it forms reacts cleanly with amines under mild conditions, it avoids the hazards of phosgene.
How should buyers store and handle it?
Keep it refrigerated in tightly closed containers, because moisture hydrolyzes it.
How can I get a price and documents?
Prices depend on quantity, packaging and destination, so please contact us with your required volume. We then send a quotation together with the CoA and SDS.
