Methanesulfonyl Chloride
Methanesulfonyl Chloride (mesyl chloride, CAS 124-63-0), min. 99.5% GC, supplied wholesale by Zyntex. Sulfonylating agent for mesylates and sulfonamides in pharmaceutical, agrochemical and fine chemical synthesis. CoA and SDS.
Description
Methanesulfonyl Chloride Product Overview
Methanesulfonyl chloride (CH3SO2Cl) is a clear, colorless to light yellow liquid with a pungent odor. It boils at about 161–163°C and reacts with water, alcohols and amines.
Chemists use it to convert alcohols into methanesulfonates (mesylates), which are excellent leaving groups for substitution and elimination reactions. It also reacts with amines to form methanesulfonamides, a structural element found in many APIs and crop protection agents. In combination with bases, it serves as a source of the highly reactive sulfene intermediate.
These reactions make it a common reagent in pharmaceutical, agrochemical and fine chemical synthesis. For the aromatic analogue, see Benzenesulfonyl Chloride, and for the corresponding acid, Methanesulfonic Acid.
Key Applications of Methanesulfonyl Chloride
Main application areas:
💊 Pharmaceutical Synthesis
Mesylation of alcohols and sulfonamide formation.
🌱 Agrochemicals
Building block for crop protection intermediates.
🧪 Fine Chemicals
Reagent for leaving group introduction.
🔬 Research
Source of sulfene in synthetic chemistry.
Methanesulfonyl Chloride Technical Specifications
| Parameter | Standard Value |
|---|---|
| Product Name | Methanesulfonyl Chloride |
| CAS Number | 124-63-0 |
| EC Number | 204-706-1 |
| Molecular Formula / Weight | CH3SO2Cl / 114.55 g/mol |
| Assay / Purity (GC) | Min 99.5% |
| Appearance | Clear, colorless to light yellow liquid |
| Density (at 20°C) | 1.480 – 1.485 g/cm3 |
| Boiling Point | 161.0°C to 163.0°C |
| Documents | CoA and SDS with every lot |
⚠️ Safety & Handling: Fatal if inhaled, toxic if swallowed or in contact with skin, causes severe skin burns and eye damage, and may cause allergic skin reactions. It reacts with water, releasing corrosive gases. Handle only in closed systems or fume hoods with full protective equipment and respiratory protection. Store in tightly closed containers in a dry, cool place, away from water, bases and alcohols. Always consult the Safety Data Sheet (SDS) for full classification and handling instructions.
Frequently Asked Questions
What is a mesylate?
A mesylate is a methanesulfonate ester formed by reacting an alcohol with it. It turns the hydroxyl group into a good leaving group for further reactions.
How should methanesulfonyl chloride be stored?
Keep it in tightly closed containers under dry conditions, away from moisture, which hydrolyzes it to methanesulfonic acid and hydrogen chloride.
How can I get a price and documents?
Prices depend on quantity, packaging and destination. Contact us with your required volume to receive a quotation together with the CoA and SDS.
