Vardenafil Hydrochloride

Vardenafil Hydrochloride is a highly potent and selective phosphodiesterase-5 (PDE5) inhibitor used in pharmaceutical research to study the biochemical pathways of vasodilation and cGMP stabilization.

SKU: 224785-91-5 Category: Tags: ,
Description
Vardenafil Hydrochloride is, furthermore, a premier pharmaceutical-grade benzenesulfonamide derivative supplied by Zyntex for the medical research, urology, and molecular pharmacology sectors. This white to off-white crystalline powder (CAS 224785-91-5) is distinguished by its high selectivity and low inhibitory concentration ($IC_{50}$) for the PDE5 enzyme. In addition, it functions by specifically preventing the hydrolysis of cyclic guanosine monophosphate (cGMP). Therefore, it is extensively utilized as a primary reagent for the study of endothelial function and as a high-potential material for next-generation vasodilatory research.

Comprehensive Product Overview

In the field of urological science and vascular dynamics, the ability to maintain elevated levels of cGMP in smooth muscle cells is a major advantage. Vardenafil Hydrochloride is specifically selected because its molecular structure allows for a more potent binding affinity to the catalytic site of PDE5 compared to earlier generation inhibitors. For instance, it is used to investigate the physiological management of erectile dysfunction (ED) and the modulation of nitric oxide pathways. Consequently, it facilitates the development of high-efficacy rapid-dissolve tablets and oral solutions with higher efficiency. As a result, Zyntex ensures that our high-purity API meets strict USP/EP requirements for trihydrate stability and residual solvent monitoring.

Moreover, the research-grade Vardenafil Hydrochloride provided by Zyntex is a vital component in the study of cross-reactivity between different PDE isoforms. This application allows for the creation of advanced profiles for systemic safety and side-effect reduction, undoubtedly pushing the boundaries of what is possible in modern pharmacological therapy. At the same time, its pharmacokinetic profile involving CYP3A metabolism is highly valued by global clinical research organizations. In short, our product serves as a dependable “precision-molecule” for companies focusing on both men’s health and sustainable healthcare infrastructure.

[Image of the PDE5 inhibitor mechanism of action]

Recently, scientific interest has surged regarding the use of Vardenafil in the study of diabetic gastroparesis and other smooth muscle disorders. Because of this, Zyntex offers specialized analytical documentation to provide safer and more convenient validation in various laboratory environments. Ultimately, by choosing Zyntex as your supplier, you secure a reliable supply chain that balances chemical potency with rigorous logistical safety. To conclude, our commitment to chemical excellence ensures that your manufacturing processes—whether in fine chemistry or clinical research—achieve the highest levels of purity and yield.

Key Industrial Applications

This high-performance enzyme blocker is specifically vital in the following four sectors:

🔬 Urology R&D

A potent agent for studying nitric oxide-mediated relaxation; thus enabling the production of high-value physiological data.

💊 Pharma Development

Key API for high-potency oral medications; consequently vital for developing stable clinical formulations.

🧪 Enzyme Kinematics

Used to investigate competitive inhibition models; undoubtedly essential for identifying new PDE targets.

🧬 Endothelial Research

Used to study the impact of cGMP on vascular health; specifically helping researchers design cardiovascular protective strategies.

Technical Specifications

ParameterStandard Value
Product NameVardenafil Hydrochloride
Assay / Purity98.0% – 102.0% (HPLC)
Molecular FormulaC23H32N6O4S · HCl
CAS Number224785-91-5

⚠️ Safety Warning: Vardenafil Hydrochloride is a potent vasodilator. Therefore, it must be handled by authorized personnel with appropriate PPE. It is contraindicated in conjunction with organic nitrates. Store in a cool, dry place and keep the container hermetically sealed to prevent moisture absorption into the trihydrate structure.

Safety and Regulatory Data

For comprehensive toxicological profiles, material safety data sheets (MSDS), and physical property validation, please refer to the official PubChem entry: Chemical Safety Data – Vardenafil HCl (224785-91-5)