Gemcitabine Hydrochloride
Gemcitabine Hydrochloride is a premium-grade, white to off-white crystalline powder compound carrying CAS number 122111-03-9. Processed under strict oncology-grade compliance, this high-purity nucleoside analog exhibits exceptional DNA synthesis inhibition and potent cytotoxic activity, making it an ideal core choice for manufacturing clinical-strength anti-cancer injectable solutions, specialized oncological therapy lines, and advanced medicinal research formulations globally.
Description
DNA Synthesis Inhibition and Cytotoxic Stability
Excellent crystalline solubility and outstanding intracellular metabolic transformation profiles provide a distinct operational edge when engineering modern fast-acting anti-cancer treatments. This active pharmaceutical solid operates by mimicking natural nucleosides to block DNA replication within actively dividing malignant cells, supplying the exact biological mechanisms required to induce apoptosis without altering raw pharmaceutical binder uniformity. It assists compounding engineers in maintaining strict dosage uniformity across high-speed sterilization and filling lines, mitigating trace instability risks within automated volumetric dosing machinery. For instance, specialized pharmaceutical facilities incorporate this hydrochloride salt as a core active component in targeted oncological injectable lines. As a consequence, it maximizes the technical throughput of automated filling machinery and continuous quality assurance checks. Consequently, Zyntex coordinates clean room crystallization paths to eliminate downstream polymorph shifts from your factory schedule.
In addition to this, Zyntex coordinates climate-controlled logistics for pilot-scale trials and advanced oncological drug research centers. The compound maintains its refined crystalline integrity under strict storage parameters, preventing heat-induced chemical breakdown or structural degradation during automated mechanical blending steps. It advances contemporary medical engineering by providing a thoroughly analyzed, highly predictable cytotoxic raw material that meets international monograph standards. Simultaneously, it remains a critical chemical standard for routine high-performance liquid chromatography (HPLC) calibrations and bioanalytical validation testing assays. In brief, our product functions as a dependable chemical foundation, supporting both the performance of commercial oncological batches and the analytical rigor of specialized industrial laboratories.
Primary Medical Sectors for Gemcitabine HCl
This high-purity crystalline active drug compound delivers crucial technical value within these four primary industrial sectors:
💉 Injectable Oncology
Primary active pharmaceutical source used for formulating uniform, clinical-grade sterile anti-cancer injectable solutions. Hence, it directly supports optimal dosage control lines.
🧪 Lyophilized Vials
Utilized as a high-purity active base to compound freeze-dried oncology vials and specialized therapeutic concentration lines. Clearly, it is key for uniform dissolving patterns.
🔬 Chromatographic Assays
Acts as an essential reference active standard for DNA inhibition metrics, assay calibration, and routine laboratory diagnostics. Resultantly, it guarantees excellent matrix clarity.
🏢 Oncology Research
Used as a professional active component for validating advanced cellular DNA-damage models and specialized liposomal drug carriers. Specifically, it confirms optimal reaction pathways.
Technical Specifications
| Parameter | Standard Value |
|---|---|
| Product Name | Gemcitabine Hydrochloride |
| Assay / Purity (HPLC) | 98.0% to 102.0% (Dry Basis) |
| Appearance | White to off-white crystalline powder |
| Specific Rotation | +48.0° to +54.0° |
| Solubility | Soluble in water; slightly soluble in methanol; insoluble in ethanol |
| CAS Number | 122111-03-9 |
📝 Safety & Handling: Gemcitabine Hydrochloride is a highly potent cytotoxic pharmaceutical active ingredient. Direct inhalation of crystalline bulk powder dust or accidental eye/skin exposure triggers immediate localized cell-cycle disruption, dermatological tissue stress, and acute respiratory tract mucosal irritation. Therefore, store strictly inside original double-sealed airtight industrial vials within a cool, exceptionally dry, and secure pharmaceutical warehouse zone protected from light, moisture, and elevated temperatures. Prevent airborne dust clouds during dispensing loops. Proper personal protective equipment (PPE)—including high-grade chemical-resistant gloves, protective safety goggles, and a certified clinical dust respirator mask—must be worn during all manufacturing handling phases. Review the Safety Data Sheet (SDS).
