Azathioprine

Azathioprine by Zyntex is a potent immunosuppressive purine antimetabolite (CAS 446-86-6). It is a critical active pharmaceutical ingredient (API) used to prevent organ rejection and treat severe autoimmune conditions by inhibiting nucleic acid synthesis.

SKU: 446-86-6 Category: Tags: ,
Description
Azathioprine ($C_{9}H_{7}N_{7}O_{2}S$) is a powerful imidazole derivative of 6-mercaptopurine. Zyntex provides this premium pharmaceutical-grade API (CAS 446-86-6) for the global healthcare, immunology research, and medicine manufacturing sectors. This compound acts as a prodrug that is converted in the body to active metabolites that disrupt DNA and RNA replication. It effectively acts as a targeted immunosuppressive agent. In addition, it specifically targets rapidly dividing cells like T-cells and B-cells. Therefore, formulators rely on it for the production of immunosuppressant tablets and injectable solutions for complex medical therapies.

Comprehensive Product Overview of Azathioprine

Exceptional therapeutic precision and proven clinical efficacy provide a major advantage in transplant medicine. Azathioprine works by incorporating “false” nucleotides into cellular genetic material, making it a “gold standard” in the manufacturing of maintenance therapy for kidney transplants. It helps clinical teams prevent the body from attacking new organs. For instance, it is a primary component in producing treatments for systemic lupus erythematosus (SLE) and rheumatoid arthritis. Consequently, it enhances long-term patient outcomes in chronic autoimmune management. As a result, Zyntex ensures high chemical stability and minimal related-substance profiles for our supply. This ensures maximum safety and predictable pharmacokinetics in your manufacturing cycles.

Moreover, Zyntex supplies high-grade Azathioprine for the gastroenterology and dermatology industries. This compound acts as a critical steroid-sparing agent in the treatment of Inflammatory Bowel Disease (IBD), including Crohn’s and Ulcerative Colitis. It pushes the boundaries of inflammatory control by enabling lower doses of corticosteroids, thereby reducing long-term side effects. At the same time, it serves as a vital tool for managing severe skin conditions like pemphigus. In short, our product serves as a dependable “molecular immune modulator.” It supports both the rigorous safety standards of hospital pharmacies and the large-scale production needs of international pharmaceutical hubs.

Recently, scientific interest in Azathioprine for its role in specialized oncology research and combination therapies for rare hematological disorders has grown. It provides high efficacy in suppressing overactive immune responses. Because of this, Zyntex offers specialized particle sizes with verified chemical profiles to meet USP, EP, and BP pharmacopeia standards. These formats suit modern tablet compression technology and precision drug delivery R&D. Ultimately, choosing Zyntex secures a reliable and transparent pharmaceutical supply chain. We balance medicinal chemistry expertise with rigorous batch-to-batch HPLC and impurity monitoring. To conclude, our commitment ensures your manufacturing processes achieve the highest levels of performance and stability.

Key Industrial Applications for Azathioprine

This essential immunosuppressive active is vital in these four sectors:

🏥 Transplant Maintenance

Essential for preventing rejection in organ transplant recipients. Thus, it is a cornerstone of post-operative pharmaceutical care.

🧬 Autoimmune Therapy

Used to treat Rheumatoid Arthritis and Lupus. Consequently, it is vital for products targeting chronic inflammatory diseases.

🩺 Gastroenterology

Primary agent for managing Crohn’s disease and Ulcerative Colitis. Undoubtedly, it is essential for long-term IBD remission.

🔬 Clinical Research

Acts as a reference standard in purine metabolism studies. Specifically, it supports the development of next-generation immune modulators.

Technical Specifications

ParameterStandard Value
Product NameAzathioprine
Molecular Formula$C_{9}H_{7}N_{7}O_{2}S$
Molecular Weight277.26 g/mol
CAS Number446-86-6

⚠️ Safety & Handling: Azathioprine is a cytotoxic agent and potential carcinogen. Therefore, handle strictly under controlled laboratory conditions using appropriate containment (glove box or fume hood) and PPE (double gloves, goggles, protective gown). Not for direct consumer use. Store in a cool, dry, and dark environment in secondary containment to prevent environmental contamination.