Xipamide
Xipamide (CAS 14293-44-8) is a potent non-thiazide sulfonamide diuretic used primarily for the treatment of essential hypertension and cardiac, renal, or hepatic edema.
Description
Comprehensive Product Overview
In the competitive landscape of antihypertensive agents, natriuretic efficiency and duration of action define the final outcome. Zyntex Xipamide is selected for its unique ability to act on the distal convoluted tubule of the nephron, promoting the excretion of sodium and chloride while maintaining a dosage-linear therapeutic effect. Therefore, we provide a high-purity crystalline powder that acts as a robust diuretic. Consequently, this versatile ingredient delivers reliable performance across a wide range of clinical conditions, ensuring effective management of fluid retention and blood pressure stabilization in patients with chronic heart failure or impaired renal function.
Zyntex supplies Xipamide in a clean, white crystalline form, optimized for easy integration into complex solid-dosage synthesis, including oral tablet compression and multi-ingredient combination therapies. Our stringent quality control measures ensure a precise impurity profile and excellent micronization capabilities for uniform drug distribution. Furthermore, this product features an intermediate duration of action, typically providing therapeutic coverage for up to 24 hours. Since it is effective at reducing peripheral resistance, you can incorporate it into various cardiovascular treatments without affecting the long-term metabolic stability of the final pharmaceutical product.
From specialized laboratory research to large-scale pharmaceutical manufacturing, this versatile sulfonamide is a staple for modern nephrology. Its consistent chemical profile ensures it functions effectively as a “thiazide-like” diuretic with a distinct structural orientation that allows for use in patients with varying degrees of renal clearance. As a result, Zyntex provides a dependable foundation for innovation in the “cardiorenal health” and “geriatric medicine” markets. Finally, our commitment to chemical quality helps your brand achieve international pharmaceutical regulatory and safety standards effortlessly.
Key Industrial Applications
This professional-grade pharmaceutical API is widely utilized in the following sectors:
❤️ Hypertension Control
The primary active ingredient for lowering blood pressure in essential hypertension by reducing vascular volume.
💧 Edema Management
Effectively treats fluid retention associated with congestive heart failure, renal disease, and hepatic cirrhosis.
💊 Fixed-Dose Combinations
Ideal for formulation with Beta-blockers or ACE inhibitors to provide synergistic antihypertensive effects.
🧪 Nephrology Research
Used as a reference compound in clinical trials studying electrolyte transport and renal hemodynamics.
Technical Specifications
| Parameter | Specification Standard |
|---|---|
| Product Name | Xipamide |
| Assay (HPLC) | 98.5% – 101.5% |
| Physical State | White to Off-White Crystalline Powder |
| Melting Point | 258°C – 262°C |
| CAS Number | 14293-44-8 |
🔬 Scientific Data: For detailed pharmacokinetics, mechanism of action, and clinical safety profiles, consult: PubChem Entry: Xipamide (External Link)
