N-Methylglucamine
Pharmaceutical-grade N-Methylglucamine (meglumine, CAS 6284-40-8), 99.0–101.5%, supplied wholesale by Zyntex. Excipient for soluble API salts, contrast agents and pH adjustment, and raw material for glucamide surfactants. CoA and SDS.
Description
N-Methylglucamine Product Overview
N-Methylglucamine (C7H17NO5), better known as meglumine, is a white crystalline powder that dissolves easily in water. Producers make it from glucose and methylamine. Its molecule combines a basic amino group with several hydroxyl groups, which gives it high water solubility and good tolerability.
Pharmaceutical companies use meglumine mainly as a counter-ion. It forms water-soluble salts with acidic APIs, which makes it possible to formulate injectables and oral solutions of poorly soluble drugs. It is also a key component of iodinated and gadolinium-based contrast agents, such as meglumine diatrizoate and gadoterate meglumine, and serves as a pH adjuster.
In the chemical industry, N-methylglucamine is the starting material for glucamide surfactants, which are mild, sugar-based surfactants used in personal care and cleaning products. For other sugar-based ingredients, see D-Mannose and Calcium gluconate.
Key Applications of N-Methylglucamine
Main application areas:
💉 Injectables
Counter-ion for soluble salts of acidic APIs.
🩻 Contrast Agents
Component of iodinated and gadolinium contrast media.
💊 Formulation
pH adjuster and solubilizer in liquid formulations.
🧼 Surfactants
Raw material for mild glucamide surfactants.
N-Methylglucamine Technical Specifications
| Parameter | Standard Value |
|---|---|
| Product Name | N-Methylglucamine (Meglumine) |
| CAS Number | 6284-40-8 |
| EC Number | 228-506-2 |
| Molecular Formula / Weight | C7H17NO5 / 195.21 g/mol |
| Assay (Titration) | 99.0% – 101.5% (On Dried Basis) |
| Appearance | White or almost white crystalline powder |
| Melting Range | Approx. 128 – 131 °C |
| Specific Optical Rotation | -15.5° to -17.0° |
| Documents | CoA and SDS with every lot |
⚠️ Safety & Handling: Not classified as hazardous under GHS, but dust may irritate the eyes. Avoid dust formation and wear eye protection. Store in tightly closed containers in a cool, dry place, protected from light. Always consult the Safety Data Sheet (SDS) for full classification and handling instructions.
Frequently Asked Questions
Why is meglumine used in contrast agents?
It forms highly water-soluble, well-tolerated salts with acidic contrast molecules, which allows concentrated injectable solutions.
Does your meglumine meet pharmacopoeia standards?
Pharmaceutical-grade material meeting USP/EP requirements is available. The applicable standard is stated on the lot CoA.
How can I get a price and documents?
Prices depend on quantity, packaging and destination. Contact us with your required volume to receive a quotation together with the CoA and SDS.
