Entecavir 1-hydrate
Entecavir 1-hydrate is a guanosine analogue that inhibits Hepatitis B virus (HBV) replication. Researchers utilize this API to study the suppression of viral DNA synthesis and the prevention of liver-related complications.
Description
Comprehensive Product Overview
In the field of antiviral drug development, the ability to interrupt multiple stages of the viral replication cycle defines therapeutic success. Specifically, Entecavir 1-hydrate functions by competing with the natural substrate, deoxyguanosine triphosphate, to inhibit all three functions of the HBV polymerase: base priming, reverse transcription of the negative strand, and synthesis of the positive strand of HBV DNA. Additionally, researchers select this molecule for its high selectivity and minimal impact on host mitochondrial DNA polymerases. Therefore, whether you investigate the mechanisms of viral “escape” or develop high-stability tablet formulations, this API delivers reliable pharmacological support across various laboratory conditions.
Zyntex maintains a transparent production chain to ensure a precise analytical profile for every batch, focusing on the limitation of enantiomeric impurities and residual dehydration markers. Moreover, our quality control team verifies every lot for water content (monohydrate ratio) and specific optical rotation to ensure the integrity of your bioassays. For instance, we optimize the purity to support the development of low-dose formulations aimed at long-term maintenance therapy. As a result, your lab receives a high-purity reagent for advanced studies into the prevention of HBV-induced cirrhosis and hepatocellular carcinoma.
Modern clinical science relies on high-quality nucleoside analogues to address the persistent challenge of chronic HBV infections globally. Because Entecavir 1-hydrate possesses a documented low rate of resistance in nucleoside-naive patients, it remains a primary focus for studies involving long-term virological suppression. Ultimately, Zyntex provides a dependable foundation for your next innovation in infectious disease management and specialized pharmaceutical engineering.
Specialized Virological Applications
This high-potency guanosine analogue is vital for the following research and production sectors:
🧬 Polymerase Inhibition
Scientists use Entecavir 1-hydrate to study the triple-action disruption of HBV DNA synthesis in hepatocyte cell lines.
🧪 Resistance Profiling
Researchers include this API in protocols focused on the genetic barrier to resistance compared to lamivudine or adefovir.
🦠 Viral Load Kinetics
Biotechnicians utilize this molecule to study the rapid clearance of HBV DNA from serum in pharmacokinetic models.
💊 Formulation Stability
This compound serves as a core tool for engineering solid oral dosage forms that maintain monohydrate integrity under stress.
Technical Specifications
| Parameter | Specification Standard |
|---|---|
| Product Name | Entecavir 1-hydrate (CAS 209216-23-9) |
| Molecular Formula | C12H15N5O3 · H2O |
| Purity | Ph. Eur. / USP Grade (Min. 99%) |
| Appearance | White to off-white crystalline powder |
| Water Content | 5.0% – 7.0% (Monohydrate) |
🔬 Scientific Data: For detailed viral inhibition curves, pharmacokinetic profiles, and toxicity data, consult: PubChem Entry: Entecavir 1-hydrate (External Link)
