Posaconazole
Pharmaceutical-grade Posaconazole (CAS 171228-49-2), 98–102%, supplied wholesale by Zyntex to licensed producers. Broad-spectrum triazole antifungal API for delayed-release tablets, oral suspensions and infusions. CoA and SDS.
Description
Posaconazole Product Overview
Posaconazole (C37H42F2N8O4) is a white to off-white crystalline powder that is practically insoluble in water. It is a triazole antifungal with activity against molds and yeasts, and is related in class to Fluconazole.
Because of its very low solubility, formulation is demanding. Pharmaceutical companies use hot-melt extrusion with polymers to make delayed-release tablets, as well as oral suspensions and intravenous concentrates, where solubilizers such as Betadex Sulfobutyl Ether Sodium keep it in solution. Similarly, other antifungal APIs in our range include Flucytosine and Nystatin.
Notably, Zyntex supplies it from qualified API producers with lot-specific documentation, only to licensed pharmaceutical companies.
Key Applications of Posaconazole
Typical uses include, for example:
💊 Delayed-Release Tablets
API for hot-melt extruded tablets.
🥄 Oral Suspensions
API for liquid formulations.
💉 Infusions
API for intravenous concentrates.
🔬 Generic Development
Development as well as reference material.
Posaconazole Technical Specifications
| Parameter | Standard Value |
|---|---|
| Product Name | Posaconazole |
| CAS Number | 171228-49-2 |
| Molecular Formula / Weight | C37H42F2N8O4 / 700.78 g/mol |
| Assay / Purity (HPLC) | 98.0% to 102.0% (Dry Basis) |
| Appearance | White to off-white crystalline powder |
| Residue on Ignition | Max 0.1% |
| Documents | CoA as well as SDS with every lot |
⚠️ Safety & Handling: Pharmacologically active substance that may damage the unborn child. Avoid inhalation of dust and contact with skin, and also wear gloves, eye protection and respiratory protection. Store in tightly closed containers in a cool, dry place. Always consult the Safety Data Sheet (SDS), because it contains the full classification and handling instructions.
Frequently Asked Questions
Why is posaconazole formulated by hot-melt extrusion?
Because it is practically insoluble in water, hot-melt extrusion with polymers creates a dispersion that dissolves and absorbs much better.
Who can purchase this API?
Only pharmaceutical companies holding the licenses required for API purchase as well as use in their country.
How can I get a price and documents?
Prices depend on quantity, packaging and destination, so please contact us with your required volume. We then send a quotation together with the CoA and SDS.
