Posaconazole
Posaconazole is a premium-grade, white to off-white crystalline powder triazole antifungal drug compound carrying CAS number 171228-49-2. Processed under strict pharmaceutical compliance, this high-purity antimycotic active substance exhibits exceptional lanosterol 14α-demethylase inhibition efficiency and reliable molecular stability, making it an ideal core choice for manufacturing specialized deep systemic anti-infective tablets, advanced delayed-release oral suspensions, and modern pharmacological testing lines globally.
Description
Zyntex supplies high-purity Posaconazole (CAS 171228-49-2) tailored specifically for global pharmaceutical manufacturing plants, hematology research laboratories, and international organic synthesis loops.
Functioning as a highly specific ergosterol biosynthesis disruptor and cell membrane terminator, it delivers precise substance profiles that ensure uniform dry batch integration and highly predictable dissolution kinetics in compound manufacturing matrices. Furthermore, its strictly minimized chemical volatile impurities and optimized crystal particle size geometry make it an ideal selection for sensitive oral suspension and delayed-release tablet compounding. Accordingly, formulation scientists specify this active substance to stabilize modern lipophilic carriers and maintain exact concentration integrity across continuous processing cycles.
Enzymatic Blockade and Amorphous Dispersion Stability
Excellent crystalline density distribution and outstanding intracellular molecular binding affinity provide a distinct operational edge when engineering modern fast-acting antimycotic compounds. This active pharmaceutical solid operates by blocking cytochrome P450-dependent enzyme pathways to target deep fungal pathogens, supplying the exact chemical mechanisms required to induce structural mold decay without altering matrix uniformity. It assists compounding engineers in maintaining strict dosage uniformity across high-speed hot-melt extrusion and wet granulation lines, mitigating trace instability risks within automated volumetric dosing machinery. For instance, specialized pharmaceutical facilities incorporate this lipophilic triazole powder as a core active component in targeted prophylaxis formulations for immunocompromised manufacturing runs. As a consequence, it maximizes the technical throughput of automated processing machinery and continuous quality assurance checks. Consequently, Zyntex coordinates clean room crystallization paths to eliminate downstream polymorph shifts from your factory schedule.
In addition to this, Zyntex coordinates climate-controlled logistics for pilot-scale trials and advanced infectious disease drug research centers. The compound maintains its refined crystalline integrity under strict storage parameters, preventing moisture-induced chemical breakdown or structural degradation during automated mechanical blending steps. It advances contemporary medical engineering by providing a thoroughly analyzed, highly predictable broad-spectrum raw material that meets international monograph standards. Simultaneously, it remains a critical chemical standard for routine high-performance liquid chromatography (HPLC) plasma validation assays and microbiological susceptibility testing loops. In brief, our product functions as a dependable chemical foundation, supporting both the performance of commercial clinical batches and the analytical rigor of specialized industrial laboratories.
Primary Medical Sectors for Posaconazole
This high-purity crystalline active drug compound delivers crucial technical value within these four primary industrial sectors:
💊 Delayed-Release Tablets
Primary antimycotic hammadde source used for formulating uniform gastro-resistant oral solid dosages. Hence, it directly supports optimal bio-availability control lines.
🧪 Clinical Suspensions
Utilized as a high-purity active base to compound professional oral liquids designed for intensive prophylactic therapy loops. Clearly, it is key for uniform dissolving patterns.
🔬 Susceptibility Bioassays
Acts as an essential molecular standard for minimum inhibitory concentration (MIC) testing and resistance tracking assays. Resultantly, it guarantees excellent matrix clarity.
🏢 Deep Mycoses Research
Used as a professional active component for validating advanced synergetic enzyme blockades and invasive Aspergillus interaction models. Specifically, it confirms optimal reaction pathways.
Technical Specifications
| Parameter | Standard Value |
|---|---|
| Product Name | Posaconazole |
| Assay / Purity (HPLC) | 98.0% to 102.0% (Dry Basis) |
| Appearance | White to off-white crystalline powder |
| Residue on Ignition | Max 0.1% |
| Solubility | Practically insoluble in water; sparingly soluble in methanol; soluble in dichloromethane |
| CAS Number | 171228-49-2 |
⚠️ Safety & Handling (HIGHLY POTENT API): Posaconazole is a highly active, hazardous triazole therapeutic pharmaceutical compound. Direct inhalation of dust or structural skin absorption posing a severe reproductive threat, potential embryo-fetal developmental toxicity, and severe endocrine homeostatic disruptions. Therefore, store strictly inside original heavy-duty airtight industrial containment systems within a securely under-lock, professional climate-controlled pharmaceutical compound vault isolated from light, volatile trace moisture, and strictly restricted access control points. Prevent airborne dust cloud dispersion during manufacturing dispensing setups. Compulsory personal protective equipment (PPE)—including double-layered chemical-resistant nitrile gloves, tight-fitting chemical splash goggles, and a certified clinical HEPA particulate or positive-pressure respirator mask—must be worn at all handling and formulation stages. Review the Safety Data Sheet (SDS).
